Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent
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چکیده
منابع مشابه
Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent
Confronting the efficacy of a regenerative therapeutic is the degenerative environment that is characterized by neuronal loss, physical plague and glial scar barriers and inflammation. But perhaps more fundamental from a regenerative perspective, are changes in the biochemical milieu of steroid and peptide growth factors, cytokines and neurotransmitter systems. Data from multiple levels of anal...
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The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer's disease (AD) brains. In parallel, the neuroactive progesterone metabolite, allopregnanolone (APα), along with a host of other factors, is decreased in the AD brain. Results of preclinical analyses demonstrate that APα is a potent indu...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2007
ISSN: 1567-2050
DOI: 10.2174/156720507783018262